17.1 C
Wednesday, February 21, 2024

Cymbalta Options to Contemplate — Talkspace

Printed on: 30 Nov 2023

Alternatives to CymbaltaAlternatives to Cymbalta

Cymbalta (duloxetine) is a typical antidepressant for treating despair and nervousness. It’s additionally typically prescribed for diabetic peripheral neuropathy and different medical circumstances that trigger ache, like arthritis, fibromyalgia, and persistent again ache. Cymbalta is in a category of medicine referred to as serotonin-norepinephrine reuptake inhibitors (SNRIs). SNRIs stability norepinephrine and serotonin ranges — neurotransmitters related to temper regulation and application — within the mind.

Whereas Cymbalta might be very efficient for some folks, it’s not at all times the fitting medicine for everybody. It would trigger undesirable Cymbalta negative effects, hostile drug interactions, not be efficient in relieving signs, otherwise you may simply be searching for pure alternate options to Cymbalta use. Holistic therapy choices have gotten extra interesting and acquainted, whether or not mixed with medicine or remedy or when used independently. 

No matter your motive is for trying into Cymbalta alternate options, we’re diving into every little thing you might want to find out about pure treatments and different medication just like Cymbalta. 

Psychiatry and prescriptions on-line

Get an analysis and prescription on-line from a licensed psychiatric supplier to enhance your well-being.

Get began

Different Medicines to Cymbalta

There are a number of medicines that could be viable alternate options to Cymbalta for despair or different circumstances. Since each drug has distinctive traits, advantages, dangers, and negative effects, exploring every choice and checking with a healthcare supplier is important earlier than switching from Cymbalta.

1. Lexapro 

Lexapro (escitalopram) is a substitute for Cymbalta that is likely to be good for people who find themselves involved about Cymbalta’s results when used long-term. Lexapro is within the class of medicine referred to as selective serotonin reuptake inhibitors (SSRIs), which work by growing serotonin ranges within the mind to boost temper. There are a lot of elements to think about when taking a look at Cymbalta vs Lexapro.

Variations between Cymbalta and Lexapro: 

  • Cymbalta is a serotonin and norepinephrine reuptake inhibitor (SNRI) whereas Lexapro is a selective serotonin reuptake inhibitor (SSRI).
  • Cymbalta is FDA-approved to deal with extra circumstances than Lexapro.
  • There is likely to be fewer hostile negative effects of Lexapro than Cymbalta.
  • In some research, Lexapro was more practical in treating main depressive dysfunction (MDD).

Similarities between Cymbalta and Lexapro: 

  • Each can deal with main depressive dysfunction (MDD) and nervousness
  • Each medication shouldn’t be used with the rest that will increase serotonin ranges.
  • Cymbalta and Lexapro shouldn’t be used with NSAIDs or different medication that may trigger bleeding.

2.Effexor (venlafaxine)

Effexor is likely to be an excellent choice to discover because it’s one of many medication just like Cymbalta. As a result of they’re in the identical class of antidepressants — SNRIs — they work equally.

Nevertheless, it’s essential to notice that Effexor might trigger important blood strain adjustments in comparison with different antidepressants. So, monitoring your BP recurrently and consulting a medical skilled when taking this drug is essential. 

Variations between Cymbalta and Effexor: 

  • Cymbalta is used to deal with extra medical circumstances.
  • Effexor might be an choice to deal with panic dysfunction and social nervousness dysfunction.
  • Effexor is extra more likely to lower intercourse drive as a aspect impact.
  • Cymbalta is stronger and can be utilized in decrease doses.

Similarities between Cymbalta and Effexor: 

  • Cymbalta and Effexor are each SNRIs.
  • Each medication can deal with MDD and generalized nervousness dysfunction (GAD).
  • Shared negative effects embody dry mouth, drowsiness, lack of urge for food, and nausea.
  • Neither drug ought to be used along with monoamine oxidase inhibitors (MAOIs).

3. Prozac (fluoxetine)

Prozac is a typical and well-liked antidepressant medicine within the SSRI class of medicine. It’s prescribed to deal with main depressive dysfunction and obsessive-compulsive dysfunction. It’s additionally accredited to deal with the consuming dysfunction bulimia and panic dysfunction in adults.

Variations between Cymbalta and Prozac:

  • They’re in several lessons of medicine — Cymbalta is an SNRI and Prozac is an SSRI.
  • Prozac is accredited to deal with extra psychological well being circumstances.
  • Prozac can be utilized to deal with some disordered consuming circumstances.
  • Cymbalta is accredited to deal with ache associated to some medical circumstances, whereas Prozac isn’t.

Similarities between Cymbalta and Prozac:

  • Cymbalta and Prozac can be utilized to deal with main depressive dysfunction.
  • Research counsel that each medication have related efficacy and security outcomes.

4. Wellbutrin (bupropion)

Wellbutrin is an antidepressant accredited to deal with main depressive dysfunction (MDD) and seasonal affective dysfunction (SAD). It’s additionally prescribed for smoking cessation. Within the norepinephrine and dopamine reuptake inhibitors (NDRIs) class of medicine, Wellbutrin has among the identical hostile results as Cymbalta, together with the potential to trigger dry mouth, dizziness, issue sleeping or insomnia, and nausea. 

Variations between Cymbalta and Wellbutrin:

  • Cymbalta and Wellbutrin belong to totally different lessons of medicine.
  • Cymbalta could cause diarrhea and fatigue; Wellbutrin typically doesn’t.
  • Wellbutrin is likely to be a greater choice for individuals who expertise weight achieve on Cymbalta.

Similarities between Cymbalta and Wellbutrin:

  • Each medication are used to deal with sure sorts of ache.
  • Each Cymbalta and Wellbutrin might be efficient in treating despair.
Drug Class of Medicine Treatable Circumstances Widespread Aspect Results
Cymbalta (duloxetine) SNRI Main depressive dysfunction
Normal nervousness dysfunction
Nerve ache brought on by diabetes
Continual muscle and joint ache
Dry mouth
Lack of urge for food
Elevated sweating
Lexapro (escitalopram) SSRI Main depressive dysfunction
Generalized nervousness dysfunction
Dry mouth
Issue sleeping
Diarrhea or constipation
Sexual dysfunction
Dizziness or drowsiness
Effexor (venlafaxine) SNRI Melancholy
Generalized nervousness dysfunction
Panic dysfunction
Social nervousness dysfunction
Dry mouth 
Lack of urge for food
Blurred imaginative and prescient
Prozac (fluoxetine) SSRI Main depressive dysfunction
compulsive dysfunction
Panic dysfunction
Bipolar despair
Lack of urge for food
Issue sleeping
Wellbutrin (bupropion) NDRIs Melancholy
Seasonal have an effect on dysfunction
Smoking cessation
Sleep points
Dry mouth

Pure Options to Cymbalta

Medicines like Cymbalta can work properly for some folks, however others may desire a pure different. Whether or not it’s to keep away from negative effects or since you want a holistic strategy, there are a number of non-pharmaceutical Cymbalta alternate options out there.

6. Omega-Three fatty acids

Omega-Three fatty acids are recognized for coronary heart well being advantages and the power to help psychological well being. Omega-3s are essential to mind perform and efficiency, and a few analysis has proven they will cut back signs of despair. Omega-3s are discovered naturally in meals sources like salmon or they’re out there as dietary supplements.

7. Vitamin D

Generally known as the sunshine vitamin, Vitamin D can enhance temper, which could make it a possible different to Cymbalta for despair. Research have discovered that individuals with despair usually have low vitamin D ranges, so supplementing may assist.

8. L-theanine

L-theanine is a novel amino acid present in inexperienced tea leaves. It’s gained recognition lately on account of the calming impact it may have on the physique and thoughts. In analysis, l-theanine has been proven to be efficient in stress aid, temper enhancement, and improved sleep high quality.

9. Way of life adjustments 

Adjusting your life-style by specializing in wholesome habits generally is a shocking different to Cymbalta that many individuals won’t take into account. Implement the next into your days to see for those who discover a discount in depressive signs and nervousness.

  • Work out recurrently: Analysis reveals that getting the center price up releases endorphins, referred to as the feel-good hormones. Even one thing so simple as strolling briskly day by day can enhance your temper.
  • Eat wholesome: Attempt to eat a balanced food plan stuffed with nutrient-rich meals. It might not treatment your despair, however it may assist naturally carry your temper.
  • Observe mindfulness: Aware actions like meditation and journaling can change your mindset and enhance your temper.
  • Search remedy: Numerous research have confirmed the improved efficacy of mixing remedy and medicine vs. utilizing one or the opposite alone.

“Remedy is an effective way to develop perception into signs and analysis. It helps to facilitate consciousness and understanding of the problems that the individual is dealing with. You may also be taught well being coping methods to assist handle signs. Typically medicine and remedy are mixed to deal with the individual and have a constructive end result.”

Talkspace therapist Bisma Anwar, LPC, LMHC

Concerns for Switching to a Cymbalta Different

When you’re contemplating switching from a medicine like Cymbalta to a unique drug or a holistic therapy plan, there are a number of essential components to recollect. Discovering an acceptable different is simply doable if it suits your distinctive wants and targets for enchancment.

Contemplate the next:

  • Why do you need to transition from Cymbalta?
  • Do the negative effects of the drug outweigh any constructive outcomes?
  • Have you ever talked to your physician about different medicines you’re at present taking?

“You will need to work intently along with your psychiatrist when switching medicines to keep away from Cymbalta withdrawal. Focus on and be open about your signs and considerations along with your suppliers so they’re conscious of how you’re doing.”

Talkspace therapist Bisma Anwar, LPC, LMHC

Discover the Proper Different with Talkspace 

When you’re making an attempt to determine whether or not to alter medicines or take a holistic strategy to your therapy plan — or for those who’re interested in combining medication with remedy or non-pharmaceutical therapy choices — Talkspace is right here. 

Talkspace is a web-based platform with a staff of psychological well being professionals who can present remedy, prescriptions, and medicine administration.

We provide telehealth from the consolation of your private home as you make essential choices about your medicine and therapy plan. Our staff is right here that can assist you navigate the complexities of medicine adjustments.


  1. Khan A, Bose A, Alexopoulos GS, Gommoll C, Li D, Gandhi C. Double-blind comparability of Escitalopram and duloxetine in??the??acute therapy of main??depressive dysfunction. Medical Drug Investigation. 2007;27(7):481-492. doi:10.2165/00044011-200727070-00005. https://pubmed.ncbi.nlm.nih.gov/17563128/. Accessed September 24, 2023.  
  2. Kıvrak Y, Güvenç TS, Akbulut N, et al. Accelerated hypertension after venlafaxine utilization. Case Experiences in Psychiatry. 2014;2014:1-4. doi:10.1155/2014/659715. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190979/. Accessed September 24, 2023. 
  3. Eckert L, Lançon C. Duloxetine in contrast with fluoxetine and venlafaxine: Use of meta-regression evaluation for oblique comparisons. BMC Psychiatry. 2006;6(1). doi:10.1186/1471-244x-6-30. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1552056/. Accessed September 24, 2023.  
  4. Larrieu T, Layé S. Meals for temper: Relevance of dietary omega-Three fatty acids for despair and nervousness. Frontiers in Physiology. 2018;9. doi:10.3389/fphys.2018.01047. https://www.frontiersin.org/articles/10.3389/fphys.2018.01047/full. Accessed September 24, 2023. 
  5. BIČÍKOVÁ M, DUŠKOVÁ M, VÍTKŮ J, et al. Vitamin D in nervousness and affective problems. Physiological Analysis. Printed on-line 2015. doi:10.33549/physiolres.933082.https://www.biomed.cas.cz/physiolres/pdf/64%20Suppl%202/64_S101.pdf. Accessed September 24, 2023.
  6. White D, de Klerk S, Woods W, Gondalia S, Noonan C, Scholey A. Anti-stress, behavioural and magnetoencephalography results of an L-theanine-based nutrient drink: A randomised, double-blind, placebo-controlled, crossover trial. Vitamins. 2016;8(1):53. doi:10.3390/nu8010053. https://www.mdpi.com/2072-6643/8/1/53. Accessed September 24, 2023.
  7. Basso JC, Suzuki WA. The consequences of acute train on temper, cognition, neurophysiology, and neurochemical pathways: A Evaluation. Mind Plasticity. 2017;2(2):127-152. doi:10.3233/bpl-160040. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928534/. Accessed September 24, 2023.
  8. How do I select between medicine and remedy? American Psychological Affiliation. 2017. Accessed September 24, 2023. https://www.apa.org/ptsd-guideline/patients-and-families/medication-or-therapy

Talkspace articles are written by skilled psychological health-wellness contributors; they’re grounded in scientific analysis and evidence-based practices. Articles are extensively reviewed by our staff of scientific specialists (therapists and psychiatrists of varied specialties) to make sure content material is correct and on par with present trade requirements.

Our aim at Talkspace is to offer essentially the most up-to-date, precious, and goal info on psychological health-related matters to be able to assist readers make knowledgeable choices.

Articles comprise trusted third-party sources which might be both straight linked to within the textual content or listed on the backside to take readers on to the supply.

Talkspace psychological well being providers

Related Articles


Please enter your comment!
Please enter your name here

Latest Articles